Anna G. Wenzel

Education

• (2003-2006) NIH Postdoctoral Scholar; Caltech, Pasadena, CA
• (1998-2003) Ph.D., M.A.; Harvard University, Cambridge, MA
• (1994-1998) B.S.; University of California, San Diego, La Jolla, CA

Research Interests

• Asymmetric Catalysis
• Organometallic Chemistry
• Organic Synthesis

Courses Taught

• Chem81L-Science and Business of Medicinal Chemistry
• Chem116L-First-semester Organic Chemistry
• Chem117L-Second-semester Organic Chemistry
• Chem123-Advanced Organic Chemistry

Selected Research and Publications

Peer-Reviewed Articles

• King, B. H.; Wang, M. L.; Jesse, K. A.; Kaur, G.; Tran, B.; Walser-Kuntz, R.; Iafe, R. G.; Wenzel, A. G.* “Silver-Catalyzed, N-Formylation of Amines Using Glycol Ethers.” J. Org. Chem.2020, 85, 13256-13263.
  Wenzel, A. G.;
• Wenzel, A.G.;* Casper, S.; Galvin, C. J.; Beck, G. E. “Science and Business of Medicinal Chemistry: a “Bench-to-Bedside” Course for Non-Majors.” J. Chem. Ed. 2020, 97, 414-420.
• Oakley, J. V.; Stanley, T. J.; Jesse, K. A.; Cain, S. E.; Wenzel, A. G.;* Iafe, R. G.* “Gold-Catalyzed Friedel–Crafts-like Reaction of Benzylic Alcohols to Afford 1,1-Diarylmethanes.” Eur. J. Org. Chem. 2019, 42, 7063-7066.
• Vinson, A. R. S.; Davis, V. K.; Arunasalam, A.; Jesse, K. A.; Hamilton, R. E.; Shattuck, M. A.; Hu, A. C.; Iafe, R. G.; Wenzel, A. G.* “Gold-Catalyzed, SN1-Type Reaction of Alcohols to Ethers and Cbz-Protected Amines.” Synlett 2015, 26, 765-770.
• Grant-Overton, S.; Buss, J. A.; Smith, E. H.; Gutierrez, E. G.; Moorhead, E. J.; Lin, V. S. Wenzel, A. G.* “Efficient Microwave Method for the Oxidative Coupling of Phenols.” Synth. Commun. 2015, 45, 331-337.
• Lipshutz, B. H.*; Bošković, Z.; Crowe, C. S.; Davis, V. K.; Whittemore, H. C.; Vosburg, D. A.*; Wenzel, A. G.* “Green “Click” and Olefin Metathesis Chemistry in Water at Room Temperature Enabled by Biodegradable Micelles.” J. Chem. Ed. 2013, 90, 1514-1517.
• Wagner, A. M.; Knezevic, C. E.; Wall, J. L.; Sun, V. L.; Buss, J. A.; Allen, L. T.; Wenzel, A. G.* “A Copper(II)-catalyzed Sequential Michael-Aldol Reaction for the Preparation of 1,2-Dihydroquinoline Carboxylic Acid Derivatives.” Tetrahedron Lett. 2012, 53, 833-836.
• Wenzel, A. G.*; Blake, G.; Vander Velde, D. G.; Grubbs, R. H. “Characterization and Dynamics of Substituted Ruthenacyclobutanes Relevant to the Olefin Cross-Metathesis Reaction.” J. Am. Chem. Soc. 2011, 133, 6429-6439.
• Gutierrez, E. G.; Moorhead, E. J.; Smith, E. H.; Lin, V.; Ackerman, L. K. G.; Sun, V.; Grant, S.; Wenzel, A. G.* “Electron-Withdrawing Biphenyl-diol Compounds for Asymmetric Catalysis.” Eur. J. Org. Chem. 2010, 3027-3031.
• Moorhead, E. J.; Wenzel, A. G.* “Two Undergraduate Experiments in Organic Polymers: the Preparation of Polyacetylene and Telechelic Polyacetylene via Ring-Opening Metathesis Polymerization.” J. Chem. Ed. 2009, 86, 973-975.
• O’Connor, J. M.; Wenzel, A. G.; Hiibner, K. “Iridium(III)-Vinylidene Chemistry: Conversion of an Iridacyclopentadiene-Chlorido Complex and Terminal Alkynes to Iridacyclopentadiene-Vinyl Complexes.” Inorganica Chimica Acta 2008, 361, 3033-3041.
• Hong, S. H.; Wenzel, A. G.; Salguero, T. T.; Day, M. W.; Grubbs, R. H. “Decomposition of Ruthenium Olefin Metathesis Catalysts.” J. Am. Chem. Soc. 2007, 129, 7961-7968.
• Wenzel, A. G.; Grubbs, R. H. “Ruthenium Metallacycles Derived from 14-Electron Complexes. New Insights into Olefin Metathesis Intermediates.” J. Am. Chem. Soc. 2006, 128, 16048-16049.
• Ritter, T.; Hejl, A.; Wenzel, A. G.; Funk, T.; Grubbs, R. H. “Catalyst Comparison in Olefin Metathesis Reactions and Generalized Reaction Procedures.” Organometallics, 2006, 25, 5740-5745.
• Wenzel, A.; Lalonde, M. P.; Jacobsen, E. N. “Divergent Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines.” Synlett 2003, 1919-1922.
• Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives: Enantioselective Synthesis of B-Aryl-B-Amino Acids.” J. Am. Chem. Soc. 2002, 124, 12964-12965.
• O’Connor, J. M.; Chen, M.–C.; Fong, B. S.; Wenzel, A. G.; Gantzel, P. “Conversion of a Metallacyclobutene to Cobalt-Allene Complexes.” J. Am. Chem. Soc. 1998, 120, 1100-1101.
• Berkeley, E.; Hamilton, R.; Laufer, I.; Smith, B.; Gallagher, T.; Dahi, A.; Reddy, M.; Wenzel, A. G. “Brønsted Acid-Catalyzed Asymmetric Allenoate Claisen Reactions.” J. Org. Chem.–Manuscript in Press, 2024.
• Wenzel, A. G. “Chiral Auxiliaries for Sigmatropic Rearrangements.” In Comprehensive Chirality, 2ndEdition; Cossy, J., Ed.; Elsevier Ltd; Ch. 30, 2024.
• Samiee, S.; Birenbaum, M.; Wenzel, A. G. “Chemical Analysis of Amoxicillin Samples Using Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) for the Distributed Pharmaceutical Analysis Laboratory.” DPAL Instructional Manual, 2023. (https://padproject.nd.edu/get-involved/distributed-pharmaceutical-analysis-lab/)

Books

• Handbook of Metathesis, 2nd Ed.; Grubbs, R. H.; Wenzel, A. G., Eds.; Wiley-VCH: New York, Vol. 1, 2015.
• Wenzel, A. G.; Chatterjee, A. K.; Grubbs, R. H. “Olefin Cross-Metathesis.” In Comprehensive Organometallic Chemistry III: Review of the Literature 1993-2005; Ojima, I.; Hiyama, T., Eds.; Elsevier Ltd: Oxford; Vol. 11, 2006.
• Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalysis in the Enantioselective Synthesis of B-Amino Acids.” In Enantioselective Synthesis of B-Amino Acids, 2nd Ed.; Juaristi, E.; Soloshonok, V. A., Eds.; WILEY-VCH: New York, 2005.

Essays and Editorials

• Wenzel, A. G. “The Chemical Analysis of Scripps’ 2013 Olive Oil.” (Published online 7/4/2014) http://magazine.scrippscollege.edu/wp-content/uploads/files/2014-summer.pdf
• Wenzel, A. G. “Olefin Metathesis and its Application.” Molecules –Advance Editorial for Special Issue (Published online 11/10/2010)
• Wenzel, A. G. “The Scanning of Saint Michael.” (Published online 4/26/2010)